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The group is led by Dr Yalda Jamshidi, and comprises a diverse group of scientists at all levels who are passionate about genetics.

Yalda is Reader in Genomic Medicine at St George's University of London where she co-directs the Genetics Research Centre. She trained at University College London and completed postdoctoral fellowships at the Institute of Child Health and Kings College London before taking an academic position at St.George’s in 2006. 

 

research

Dr Jamshidi’s research interests focus on understanding the genetic and molecular mechanisms of electrocardiographic structure and function at the population level. She also has a key interest in the use of the latest genetic technologies to uncover the underlying genetic causes of rare inherited conditions. Her group is applying the discoveries, and novel technologies, to identify genes and pathways which can lead to increased susceptibility to rare cardiac arrhythmias, cardiomyopathies, and drug-induced cardiotoxicity. Her aim is to translate genetic discoveries into an improved understanding of human physiology through clinically-focused research, and define the role of genetics in disease diagnosis and in predicting patients’ risk of disease.

OUTREACH AND EDUCATION

Dr Jamshidi has a Postgraduate Certificate in Healthcare and Biomedical Education and has taught molecular biology and genetics to medical, BSc and PhD/MRes students. She initiated and runs the Cloning, Stem Cell Research and Regenerative Medicine module offered to medical students who choose to undertake an Intercalated BSc, and to third year Biomedical Science BSc students. She also acts as module co-ordinator for a Cardiovascular Genetics module on the MSc in Genomic Medicine offered at St George's.
She is  personal tutor to both Medical students and Biomedical Science BSc students, and is currently an external examiner for the Genomic Medicine MSc at Exeter University.

She is an elected Fellow of the Royal Society of Biology (as of April 2016), a local representative for the Genetics Society. She is a member of the editorial board for the Physiological Genomics Journal and the Journal Genes.

She is keen to share her excitement about our research with the public through seminars at local schools, interactions on social media, and talking to patient advocacy groups to see what the patients themselves want from our research. She also works with the Science Media Centre, an independent press office helping to ensure that the public have access to the best scientific evidence and expertise through the news media when science hits the headlines.

Visit our outreach page to learn more about our work outside of the lab!


LAB MEMBERS:

Jaipreet Bharj, BSc, MRes

Jaipreet Bharj, BSc, MRes

Tanya Awal, BSc

Tanya Awal, BSc

Jay is carrying out a PhD with Yalda Jamshidi and Daniel Osborn. She is looking at the role of a novel transcriptional regulator of muscle using the zebrafish model.

Tanya Awal is on the Mres in Translational Medicine pathway. Her project involves the investigation of a newly identified gene associated with a neurodevelopmental using the zebrafish model. She is co-supervised by Dr Florencia Cavodeassi.

Oliver Hines, BSc, MSc

Oliver Hines, BSc, MSc

Reza Maroofian, PhD

Reza Maroofian, PhD

Ehsan Ghayoor Karimiani, MD, MRes, PhD

Ehsan Ghayoor Karimiani, MD, MRes, PhD

Sarah Baldwin

Sarah Baldwin

Oliver Hines is working with Yalda Jamshidi and Karla Diaz-Ordaz (LSHTM) on an MRC-LID PhD project to look at machine learning and improving statistical methodology to determine causal genetic variants for heart rhythm. Oliver did his undergraduate degree at Imperial in the Department of Physics and has recently completed an MSc in Statistics in the Department of Mathematics at Imperial.

Reza recently completed his PhD entitled "Defining the genetic causes of neurodevelopmental disorders in the Amish". As an honorary post doctoral research assistant he is continuing to collaborate with us on a broad range of disorders within consanguineous families, trying to identify their underlying genetic cause.

Dr Ehsan Ghayoor Karimiani is a Consultant Medical Geneticist and Honorary Lecturer in our group. He obtained his medical degree from Azad Mashhad University of Medical Sciences, later completing his PLAB (General Medical Council Board) with full registration in the UK in 2006. He went on to complete an MRes in Molecular Medicine, and a PhD in Medical Genetics at Manchester University. His research interests include rare recessive Mendelian disorders.

Sarah Baldwin is our new undergraduate summer student for 2019. She was awarded the St Georges Biomedical Science Summer Vacation Studentship and will be working on our rare Mendelian Disease cohort.

CURRENT PROJECT STUDENTS

BSc Undergraduate Students: Emily Cooper (2018/19); Ruth Wright (2018/19)

MSc Genomic Medicine Students: Philippa Curry (2018/19); Zahra Waheed (2018/19)


KEY Collaborators

Population genetics:

Prof Harold Snieder, Dr Ilja Nolte - University of Groningen, The Netherlands

Prof Tim D Spector, TwinsUK, Department of Twin Research and Epidemiology, Kings College London, UK

Prof Nona Sotoodehnia, University of Washington, Seattle, US.

 

In vivo models:

Dr Dan Osborn, SGUL Genetics Centre

Dr Chris Carroll, SGUL Genetics Centre

 

Rare disease:

Dr Chiara Manzini, George Washington University, Washington DC, US.

Dr. Rebecca Schuele, Department Neurodegenerative Diseases, Tübingen, Germany.


PAST-LAB MEMBERS

Post-Docs:

Bram Prins

Bram Prins

Dr Dongling Zheng - Post Doc

PAST MD/PHD Students:

Following his postdoc in our group where he worked as a statistical geneticist looking at the link between rare and common genetic variation in determining cardiac conduction, Bram moved to the group of Prof Ele Zeggini at the Wellcome Sanger Institute in Cambridge in 2015.

Reza Maroofian

Reza Maroofian

Reza completed his PhD in 2018. He is now working as a post-doctoral researcher in the lab of Prof Henry Houlden, at the University College London Queen Square Institute of Neurology.

Evmorfia Petropoulou

Evmorfia Petropoulou

Chrysoula Dalageorgou

Chrysoula Dalageorgou

Evmorfia completed her PhD in 2017, entitled “Investigating the Underlying Genetic Mechanisms of Inherited Cardiac Disorders”, following a Masters in Research project developing hESC-cardiomyocytes as a disease model. She is now a Project Scientist at University Hospital Düsseldorf, Germany.

Chrysoula completed her PhD in 2012. She now works in the Centre for Heart Muscle Disease, led by Prof Perry Elliott, which is part of the Institute of Cardiovascular Science at University College London.

past MSC Genomic Medicine students:

Aoife Ruane (2017/18)

Isobel White (2017/18)

Lydia Inema (2016/17)

past MRes Biomedical Science Students:

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William Stockdale Cardiovascular Genetics (Distinction) 2014/15

Jaipreet Bharj Cardiovascular Genetics (Merit) 2013/14 Evmorfia Petropoulou Cardiovascular Genetics (Distinction) 2012/13 Merve Uysaloglu Cardiovascular Genetics (Distinction) 2012/13

Thulasi Nithiyananthan Cardiovascular Genetics (Distinction) 2007/08

PAST undergraduate SUMMER/PLACEMENT Students:

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Siavash Tohidi, Yusof Ali (2015/2016)

Hamza Naeem, Ali Sohail, Chantal Roberts, Huda Khalif (2014/2015)

Sokol Shala, Joao Pequeno Vieira (2013/2014)

Nardos Abraham (2016/2017)

Heather Jeffery (awarded Genetics Society summer studentship, 2016)

 

 

IT'S NOT ALL HARD WORK

Fun whilst attending the Functional Genomics Conference in Santorini, Greece.

Fun whilst attending the Functional Genomics Conference in Santorini, Greece.

Quick lunch in the local Tooting eatery.

Quick lunch in the local Tooting eatery.

With PhD students past and present, Jaipreet Bharj, Evmorfia Petropoulou and Chrysoula Dalageorgou, at the American Society of Human Genetics Conference in San Diego, US.

With PhD students past and present, Jaipreet Bharj, Evmorfia Petropoulou and Chrysoula Dalageorgou, at the American Society of Human Genetics Conference in San Diego, US.

At Graduation, Barbican, London.

At Graduation, Barbican, London.

With former PhD student Chrysoula Dalageorgou at the Functional Genomics Conference in Santorini, Greece.

With former PhD student Chrysoula Dalageorgou at the Functional Genomics Conference in Santorini, Greece.

Former PhD student Evmorfia Petropoulou checking out the Boston Pizza whilst attending the Heart Rhythm Congress.

Former PhD student Evmorfia Petropoulou checking out the Boston Pizza whilst attending the Heart Rhythm Congress.